Leucocyte- and Platelet Rich Fibrin or L-PRF is the 2nd generation platelet concentrate.
- Natural and Autologous: Derived from the patient's own blood, ensuring compatibility and reducing the risk of adverse reactions.
- Natural Fibrin Network: Rich in platelets, growth factors, and cytokines derived from the patient's blood, promoting rapid healing.
- Preparation: No need for complex biochemical manipulation or external agents like anticoagulants or thrombin, minimizing errors during preparation.
- Centrifugation Process: Blood is centrifuged in sterile tubes without anticoagulants, activating platelets and initiating the clotting process.
- Fibrin Matrix Scaffold: Platelets and leukocytes are retained in the middle part of the tube, forming a fibrin matrix scaffold. Forming a strong and pliable fibrin matrix containing concentrated platelets and leukocytes, providing a scaffold for cellular migration.
- Compression of L-PRF Cloth: The resulting L-PRF cloth is compressed for 5 minutes to obtain a strong and slightly elastic membrane suitable for suturing.
- Rich in Growth Factors and Cytokines: Contains proteins that promote rapid healing, especially during the critical first seven days post-placement.
- Platelet Activation: Platelets are activated by contact with tube walls, initiating the coagulation process.
- Efficient Cell Migration and Proliferation: Facilitates these processes without chemical additives or bovine thrombin.
- Promotes Tissue Regeneration: Facilitates efficient cell migration and proliferation without the need for chemical additives.
- Economic and Cost-effective: Offers a cost-effective solution for tissue regeneration procedures.
- Thin Matrix and Plugs: Produces thin, compressed layers suitable for suturing and surgical applications.
- Slow Release: Provides sustained release of growth factors over at least seven days, supporting long-term tissue regeneration.
- Matrix for Bone Grafts: Can serve as a scaffold for bone graft materials, enhancing its utility in regenerative medicine procedures..
- Key Features and Benefits: Simple and economic, 100% autologous, thin fibrin matrix and plugs, inclusion of leukocytes, platelets, and fibrin, slow release of bioactive molecules for at least seven days.
