An important goal of the modern surgery is low invasiveness and optimal clinical healing. Especially in “regenerative surgery”, an aspect that became extremely important in oral surgery.

Applications of regenerative surgery in oral surgery:

• Horizontal/vertical bone augmentation: Compensates for alveolar resorption after tooth loss and restores bone volume for implant placement.
• Ridge preservation: Prevents alveolar ridge resorption after tooth extraction, preserving bone volume for future implant placement.
• Sinus augmentation: Creates bone in the maxillary sinus to support dental implants.
• Periodontal ligament and bone regeneration: Restores tissue and bone lost due to periodontal disease to support tooth stability.
• Restoration of gingiva: Restores gum tissue lost due to trauma or tooth loss, improving aesthetics and function.

(Reksodiputro et al. 2014, Lara et al. 2015).

Evolution of platelet concentrates:

1st generation: Platelet concentrates such as PRP (Platelet-Rich Plasma) and PRGF (Plasma Rich in Growth Factors) have been used worldwide. However, the clinical benefits were inconsistent due to the complexity of preparation and variation in protocols.

2nd Generation: Platelet concentrates such as L-PRF (Leucocyte- and Platelet Rich Fibrin) offer a more promising alternative. L-PRF is easier to prepare and use clinically, more cost-effective (10% or less than previous products) and safer (no blood manipulation or additives except a 12-minute centrifugation). Its versatility goes beyond oral surgery and is used in a variety of medical fields, including brain surgery, wound care, alternatives to skin grafts and fistula closure.