Leukocyte- and Platelet-Rich Fibrin (L-PRF) has gained global recognition as a versatile autologous biomaterial in regenerative dentistry. Its natural 3D fibrin matrix supports angiogenesis, osteogenesis, soft tissue healing, and offers excellent mechanical handling—making it ideal for both hard and soft tissue procedures.

This newly published review presents evidence-based protocols and step-by-step clinical guidelines for L-PRF use in:

    •    Alveolar ridge preservation

    •    Guided tissue and bone regeneration

    •    Sinus floor augmentation (lateral and transcrestal)

    •    Periodontal and endodontic surgery

    •    Management of medication-related osteonecrosis of the jaw (MRONJ)

The document emphasizes standardization and reproducibility to optimize healing outcomes and minimize variability in clinical results.

All devices and blood tubes for L-PRF preparation are available via Allmedics.

A valuable contribution to the field by leading experts in regenerative dentistry.

By M. Quirynen, J. Blanco, H.-L. Wang, N. Donos, A. Temmerman, A. Castro, and N. Pinto.