Literature APAG

Dong et al., 1995. Infrared spectroscopic studies of lyophilization- and temperature-induced protein aggregation, J Pharm Sci, 84, 415-424.

Ronald M Sánchez-Avila et al. Plasma rich in growth factors eye drops to treat secondary ocular surface disorders in patients with glaucoma International. MedicalCase Reports Journal 2018:11 97–103

Sivaraman B, Latour RA. The adherence of platelets to adsorbed albumin by receptor-mediated recognition of binding sites exposed by adsorption-induced unfolding. Biomaterials. 2010 Feb;31(6):1036-44. doi: 10.1016/j.biomaterials.2009.10.017. Epub 2009 Oct 27.

Stirpe A, Pantusa M, Rizzuti B, Sportelli L, Bartucci R, Guzzi R. Early stage aggregation of human serum albumin in the presence of metal ions. Int J Biol Macromol. 2011 Oct 1;49(3):337-42. doi: 10.1016/j.ijbiomac.2011.05.011. Epub 2011 May 23.

Wang, 2005. Protein aggregation and its inhibition in biopharmaceutics, International Journal of Pharmaceutics, 289, 1-30.

Yoshiko Moriyama and Kunio Takeda. Secondary Structural Changes of Intact and Disulfide Bridges-Cleaved Human Serum Albumins in Thermal Denaturation up to 130℃ – Additive Effects of Sodium Dodecyl Sulfate on the Changes. J. Oleo Sci. 66, (5) 521-529 (2017). doi: 10.5650/jos.ess16228

Use of APAG device as per Dr. Gregorio Martinez’s Protocol (April 2019 - Rev. 00)


Lee SB, Lim AR, Rah DK, Kim KS, Min HJ. Modulation of heat shock protein 90 affects TGF-beta-induced collagen synthesis in human dermal fibroblast cells. Tissue Cell. Dec 2016;48(6):616-623.

-- Use of APAG device as per Dr. Gregorio Martinez’

Noble-Daoud Aniss A, Magdy Zaazaa A, Rabie Abdalla Seleh M. Anti-arthritic effects of platelets rich plasma and hyaluronic acid on adjuvant-induced arthrtitis in rats. International Journal of Pharmacology 16(1): 33-46; 2020

Zhang J, Yin C, Zhao Q et al. Anti-inflammation effects of injectable platelet-rich fibrin via macrophage and dentritic cells. J Biomed Mater Res; 2019

Belebecha V, Casagrande R, Urbano MR et al. Effect of the platelet-rich plasma covering of polypropylene mesh on oxidative stress, inflammation, and adhesion. Int Urogynecol J 31: 139-147; 2020

Nasirzade J, kargarpour Z, Hasannia S et al. Platelet-rich fibrin elicits an anti-inflammatory response in macrophages in vitro. J Periodontol 91: 244-252; 2020

CGF Literature

Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation-A Narrative Review Eitan Mijiritsky 1 2, Haya Drora Assaf 3,Oren Peleg 1, Maayan Shacham 4, Loredana Cerroni 5, Luca Mangani 5 Affiliationsj molecular sciences article analysis of cgf biomolecules, structure and cell population: characterization of the stemness features of cgf cells and osteogenic potential eleonora stanca 1,*, nadia calabriso 2 , laura giannotti 1, paola nitti 3,4 , fabrizio damiano 1 ,benedetta di chiara stanca 1, maria annunziata carluccio 2 , giuseppe egidio de benedetto 4 ,christian demitri 3, andrea palermo 5, franco ferrante 6 , luisa siculella 1,* and alessio rochira 1,* int. j. mol. sci. 2021, 22, 8867 2 of

biological characterization and in vitro effects of human concentrated growth factor preparation: an innovative approach to tissue regeneration january 2015 biology and medicine 07(05) doi:10.4172/0974-8369.1000256

cgf- clinical studie jan.2021 - yüce mo, adalı e, işık g. the effect of concentrated growth factor (cgf) in the surgical treatment of medication-related osteonecrosis of the jaw (mronj) in osteoporosis patients: a randomized controlled study. clin oral investig. 2021 - jan 3. doi: 10.1007/s00784-020-03766-8.

cgf- clinical studie jan, 2021 - adalı e, yüce mo, günbay t, günbay s. does concentrated growth factor used with allografts in maxillary sinus lifting have adjunctive benefits? j oral maxillofac surg. 2021 jan;79(1):98-108. doi:10.1016/j.joms.2020.07.217.

cgf clinical studie, dec. 2020 - fang h, liu q, cheng t, yang c, wu r, yang z, yang d. innovative use of concentrated growth factors combined with corticosteroids to treat discoid lupus erythematosus alopecia: a case report. j cosmet dermatol. 2020 dec 23. doi: 10.1111/jocd.13904.

cgf- in vitro studie, oct. 2020 rochira a, siculella l, damiano f, palermo a, ferrante f, carluccio ma, calabriso n, giannotti l, stanca e. concentrated growth factors (cgf) induce osteogenic differentiation in human bone marrow stem cells. biology (basel). 2020 oct 30;9(11):370. doi: 10.3390/biology9110370

cgf clinical studie, aug. 2020 tan pc, zhang pq, xie y, gao ym, li qf, zhou sb, liu q, liu k. autologous concentrated growth factors combined with topical minoxidil for the treatment of male androgenetic alopecia: a randomized controlled clinical trial. facial plast surg aesthet med. 2020 aug 21. doi:10.1089/fpsam.2020.0288.

cgf in vitro studie, aug 2020- wei z, liu s, chen z, huang x. comparison of the effect on proliferation of osteoblasts mc3t3-e1 between the concentrated growth factor extract and the platelet-rich fibrin extract. zhong nan da xue xue bao yi xue ban. 2020 aug 28;45(8):901-908. english, chinese.doi: 10.11817/j.issn.1672-7347.2020.190037. and anti-magnetic r

cgf in vitro studie, jul. 2020 - zhang m, zhang t, tang y, ren g, zhang y, ren x. concentrated growth factor inhibits uva-induced photoaging in human dermal fibroblasts via the mapk/ap-1 pathway. biosci rep. 2020 jul 31;40(7):bsr20193566. doi: 10.1042/bsr20193566.

cgf clinical studie, may. 2020 - kamal a, salman b, abdul razak nh, qabbani aa, samsudin ar. the efficacy of concentrated growth factor in the healing of alveolar osteitis: a clinical study. int j dent. 2020a may 12;2020:9038629. doi: 10.1155/2020/9038629.

cgf clinical studie, apr. 2020 - çankaya zt, ünsal b, gürbüz s, bakirarar b, tamam e. efficiency of concentrated growth factor in the surgical treatment of multiple adjacent papillary losses: a randomized, controlled, examiner-blinded clinical trial using cad/cam. int j periodontics restorative dent. 2020 mar/apr;40(2):e73-e83. doi: 10.11607/prd.4359. richiesto pdf

clinical studie , apr. 2020- brignardello-petersen r. concentrated growth factor seems to have benefits in outcomes after extraction of partially impacted third molars. j am dent assoc. 2020 apr;151(4):e29. doi: 10.1016/j.adaj.2019.10.018. richiesto pdf

clinical studie, apr. 2020 -zhao qm, gao j, huang xx, chen xp, wang x. concentrated growth factors extracted from blood plasma used to repair nasal septal mucosal defect after rhinoplasty. aesthetic plast surg. 2020 apr;44(2):511-516. doi: 10.1007/s00266-019-01474-7.

clinical studie, mar. 2020 - sun jl, wang jj, cui zj, meng qn, liu xj, wang x, yu zg. [clinical effects of concentrated growth factor combined with plasma albumin gel in treating facial depressed scar]. zhonghua shao shang za zhi. 2020 mar 20;36(3):210-218. chinese. doi: 10.3760/cma.j.cn501120-20190930-00389.

clinical studie, feb. 2020 - kao ch. use of concentrate growth factors gel or membrane in chronic wound healing: description of 18 cases. int wound j. 2020 feb;17(1):158-166. doi: 10.1111/iwj.13250.

clinical studie, feb. 2020- torul d, omezli mm, kahveci k. evaluation of the effects of concentrated growth factors or advanced platelet rich-fibrin on postoperative pain, edema, and trismus following lower third molar removal: a randomized controlled clinical trial. j stomatol oral maxillofac surg. 2020 dec;121(6):646-651. doi: 10.1016/j.jormas.2020.02.004.

in vitro studie, jan 2020 - borsani e, buffoli b, bonazza v, brunelli g, monini l, inchingolo f, ballini a, rezzani r, rodella lf. in vitro effects of concentrated growth factors (cgf) on human sh-sy5y neuronal cells. eur rev med pharmacol sci. 2020 jan;24(1):304-314.

clinical studie, dec. 2019 - amato b, farina ma, campisi s, ciliberti m, donna vd, florio a, grasso a, miranda r, pompeo f, farina e, serra r, cirocchi r, calemma f, rocca a, compagna r. cgf treatment of leg ulcers: a randomized controlled trial. open med (wars). 2019 dec 24;14:959-967. doi: 10.1515/med-2019-0113.

clinical studie, dec. 2019 - krishnakumar d, mahendra j, ari g, perumalsamy r. a clinical and histological evaluation of platelet-rich fibrin and cgf for root coverage procedure using coronally advanced flap: a split-mouth design. indian j dent res. 2019 nov-dec;30(6):970-974. doi: 10.4103/ijdr.ijdr_16_18.

in vitro studie, may 2019- chen j, jiao d, zhang m, zhong s, zhang t, ren x, ren g. concentrated growth factors can inhibit photoaging damage induced by ultraviolet a (uva) on the human dermal fibroblasts in vitro. med sci monit. 2019 may 20;25:3739-3749.doi: 10.12659/msm.913967.

in vitro studie, feb. 2019 - li x, yang h, zhang z, yan z, lv h, zhang y, wu b. concentrated growth factor exudate enhances the proliferation of human periodontal ligament cells in the presence of tnf‑α. mol med rep. 2019 feb;19(2):943-950. doi: 10.3892/mmr.2018.9714.

evidence for contamination of silica microparticlesin advanced platelet-rich fibrin matrices prepared using silica-coated plastic tubes * correspondence:; tel.: +81-25-262-7559 received: 20 may 2019; accepted: 18 june 2019; published: 19 june 2019

blood tubes literature:received: 4 may 2016 | revised: 29 july 2016 | accepted: 23 august 2016doi 10.1002/jemt.22772 how the different material and shape of the blood collection tube influences the concentrated growth factors production veronica bonazza1 | elisa borsani1,2 | barbara buffoli1,2 | stefania castrezzati1 |rita rezzani1,2 | luigi fabrizio rodella1,2 article in odontology · january 2020 doi: 10.1007/s10266-020-00486-zacute cytotoxic effects of silica microparticles used for coating of plastic blood-collection tubes on human periosteal cells

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